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Nauck MA, Heimesaat MM, Behle K, Holst JJ, Nauck MS, Ritzel R, Hfner M, Schmiegel WH

For instance, central administration of GLP-1R agonists increases the ability of insulin to suppress endogenous glucose production (Knauf et al., 2005

It appears to be genuinely synergistic, with the combination producing more weight loss than you would expect from simply adding the individual effects together

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Efficacy and safety of once-weekly subcutaneous semaglutide on weight loss in patients with overweight or obesity without diabetes mellitusA systematic review and meta-analysis of randomized controlled trials

Oral semaglutide was inferior to orforglipron in ACHIEVE-3 head-to-head