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Since GLP-1 medications slow how fast food leaves your stomach, large meals can feel heavy and cause bloating

I havent seen that, personally, he says

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The effect of substitution on binding affinity (GLP-1 radioligand competition IC 50 ) and potency (cAMP activity EC 50 ) was, however, much larger for Phe 28 (1300/1000-fold decrease in affinity/potency) and Ile 29 (93/27-fold reduction) compared with Leu 32 (17/twofold decrease), indicating that interactions of Phe 28 and Ile 29 with the conserved hydrophobic core of the ECD of GLP-1R are particularly important (Adelhorst et al., 1994)

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The thigh and upper arm are alternative sites for rotation