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Given that nausea, vomiting, diarrhea, and constipation are common adverse effects of GLP-1 medicationsparticularly during dose titrationselecting a magnesium supplement that does not exacerbate these symptoms is clinically prudent

Consistent with this, glucagon-stimulation of insulin secretion is decreased in islets isolated from -cell-specific GLP-1R KO mice [173]

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PEER REVIEW The peer review history for this article is available at Supporting information ACKNOWLEDGMENTS The authors thank the participants, investigators and site staff involved in the STEP 14 trials

Mudaliar S, Henry RR: Incretin therapies: effects beyond glycemic control