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This also activates pro-inflammatory mediators in adipose tissue which together ultimately activate hepatic stellate cells.[94], [95], [96]CVC was evaluated in a phase IIb, randomised, placebo-controlled, multinational study of 289 patients with biopsy proven NASH (NAS 4, with fibrosis stage 1-3) and diabetes or metabolic syndrome (CENTAUR)

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AMA House of Delegates Adopts Policy to Recognize Obesity as a Disease

these should be considered within a broader plan targeting the underlying trigger