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The SURPASS-CVOT trial, an ongoing cardiovascular outcomes study with approximately 12,500 participants, will provide more definitive long-term safety data regarding malignancy risk

Most patients begin to notice subtle changes in appetite and energy levels within the first few weeks of treatment

Take injections consistently on the same day each week, rotating injection sites

Proper injection technique prevents bruising, ensures accurate dosing, and reduces the already low risk of infection at the injection site

You should speak to your GP if: You are currently taking any prescription weight loss medication (such as semaglutide, liraglutide, tirzepatide, naltrexone/bupropion, or orlistat) and are planning to try for a baby You have been trying to conceive for 12 months without success (or 6 months if you are over 35), or sooner if you have known risk factors such as irregular or absent periods, suspected tubal disease, severe endometriosis, or a history of pelvic surgery or sexually transmitted infection You have a BMI over 30 and are concerned about how this may affect your fertility or pregnancy You have a condition such as PCOS, hypothyroidism, or type 2 diabetes that may interact with both weight and fertility You have taken weight loss medication and have recently discovered you are pregnant You are using anti-obesity medicines and are not using reliable contraception Your GP can review your current medications, advise on an appropriate washout period before conception, and refer you to specialist services if needed

A single hot night likely causes modest degradation, perhaps a few percentage points of potency loss