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Common side effects Microdosing usually produces a quieter side-effect profile than standard GLP-1 dosing

Perioperative use of glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter 2 inhibitors for diabetes mellitus

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Lower-dose protocols may allow for longer-term use with fewer side effects, which matters because inflammation-driven damage accumulates slowly over time

About the review This review aims to simultaneously promote GLP-1 RA research and enhance users' understanding by synthesizing evidence from recent landmark trials, thereby providing a comprehensive picture of the potential of these drugs as more than just metabolic modulators

In a phase 2 clinical trial, CagriSema reduced HbA1c by 2.2% (p = 0.075) in comparison with semaglutide 2.4 mg alone [101]