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The low-risk group also includes older patients with primary papillary tumors smaller than 5 cm without evidence of gross extrathyroidal invasion, and older patients with follicular cancer without major capsular invasion or blood vessel invasion.[13] Using these criteria, a retrospective study of 1,019 patients showed that the 20-year survival rate was 98% for patients with low-risk disease and 50% for patients with high-risk disease.[13] A retrospective surgical series of 931 previously untreated patients with differentiated thyroid cancer found that age older than 45 years, follicular histology, primary tumor larger than 4 cm (T2T3), extrathyroidal extension (T4), and distant metastases were adverse prognostic factors.[16,17] Favorable prognostic factors included female sex, multifocality, and regional lymph node involvement.[16] However, other studies have shown that regional lymph node involvement had no effect [18,19] or had an adverse effect on survival.[14,15,20] Another retrospective series of 1,807 patients found that the presence of distant metastases was most predictive of survival, followed by age.[21] An age cutoff of 55 years was identified as most predictive of survival

Members of this family are responsible for responding to diverse extracellular cues, such as odorants, neurotransmitters, and hormones (such as adrenaline, which binds to adrenergic receptors)