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Diphenhydramine: Another antihistamine with similar effects

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From a pharmacological perspective, these drugs work through different mechanisms and are metabolised via different pathways, which reduces the likelihood of direct drug-drug interactions

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Critics argued this was both medically suboptimal (small-molecule drugs are often more convenient for patients, more orally bioavailable, and more amenable to global manufacturing) and economically distorting (it adds complexity and cost to the therapy development process without clinical justification)

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Aliment Pharmacol Ther 50(2):193203

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Avoiding these foods is generally advisable, although certain subcategories of ultra-processed foods may have neutral or net positive health effects (e.g., those rich in whole grains, fruit, yogurts, or seafood), depending on their ingredients, processing, and additives [294,295]

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FDA vs EMA: how medicine approvals work Companies commonly seek FDA approval for the United States first, then submit to the EMA for the European Union a few months later

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