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However, exendin-4 does not change the membrane potential as well as the firing rate of melanin-concentrating hormone (MCH) neurons in the lateral hypothalamus (Acuna-Goycolea and van den Pol, 2004)

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These molecules have demonstrated tremendous positive results in clinical trials, demonstrating that a better mechanistic understanding of the action of these molecules could highlight their pleiotropic effects, strengthening their clinical outcomes

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So, when blood sugar levels are elevated particularly after eating GLP-1 agonists spur insulin production leading to lower blood sugar levels, which is ultimately beneficial for controlling type 2 diabetes