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Participants on the highest dose of Retatrutide lost, on average, 28.3% of their body weight over 80 weeks

However, it's typically considered an adjunctive treatment option - meaning it should be used alongside dietary changes and increased physical activity rather than being relied upon solely for weight reduction efforts

Retatrutide is newer, so the long-term safety data is thinner

[1] [2] These contraindications are based on the theoretical risk suggested by animal studies and the known genetic predisposition to MTC in these populations

The regulatory dates in this post are current as of publication

Both medications are taken once each day and can take several weeks to start working