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Dehydration can amplify side effects such as nausea, constipation, fatigue, and dizziness

Multiple factors contribute to this effect

Chappuis, Genve (Mdecine des voyages)

Yes, indeed, we can, and those prescribed quinine had a 27 percent increased risk of acute kidney injury, which is not as bad as death: Association Between Long-term Quinine Exposure and All-Cause Mortality. Following 175,000 people for about six years, researchers found that those who were taking about 200 mg of quinine a day had a 25 percent greater risk of dying

GLP-1R was also expressed in a type I collagen abundant lesion of the P-IA and FA, especially in spindle-shaped fibroblasts (Figures 4ko)

And that can absolutely be the case