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It is important to note that semaglutide is not recommended during pregnancy or breastfeeding
Finally, patients on GLP-1 RAs undergoing elective surgical procedures may need the therapy held before surgery [61]

We did a meta-analysis of available trial data using a random-effects model to calculate overall hazard ratios (HRs) and 95% CI (confidence intervals)

Key Legal Claims in GLP-1 Vision Loss Cases Against Drug Manufacturers Like Novo Nordisk and Eli Lilly GLP-1 Vision Loss Lawsuit : Personal injury claims related to GLP-1 drugs vision side effects center on several fundamental legal theories that establish manufacturer liability

Research, including recent findings from the SELECT trial, indicates that GLP-1 agonists like semaglutide can significantly reduce the risk of major cardiovascular events, such as heart attacks and strokes, especially in individuals with obesity but without diabetes

Forbes contributor Bruce Japsen reported in June 2026 that a growing share of health plans and employers are refusing to cover the drugs for weight loss, restricting coverage to diabetes indications or requiring prior authorisation hurdles that most patients cannot clear
