long term glp 1 use Long-term GLP-1 therapy requires individualized strategies… As GLP-1 receptor agonists gain traction in managing obesity, diabetes and cardiometabolic conditions, questions about long-term tolerance persist. Best practices for managing patients on Metabolic surgery and GLP-1 agonists

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Willard FS, Douros JD, Gabe MB, Showalter AD, Wainscott DB, Suter TM, Capozzi ME, van der Velden WJ, Stutsman C, Cardona GR, Urva S, Emmerson PJ, Holst JJ, DAlessio DA, Coghlan MP, Rosenkilde MM, Campbell JE, Sloop KW

Comparing Semaglutide, Tirzepatide, and Dual-Compound Options for Younger Users Semaglutide targets GLP-1 receptors only, making it suitable for patients seeking single-pathway activation or those sensitive to dual-mechanism agents

[10] [11] Whilst direct evidence linking sleep specifically to GLP-1 is still emerging, poor sleep is associated with impaired glucose tolerance and increased appetiteconditions that GLP-1 normally helps regulate

One risk mitigation strategy is for elective patients to have a clear fluid diet for the day before surgery

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