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Description
The importance of GLP-1 and GLP-1R in blood glucose modulation has been fully recognized, mainly focused on the pancreas and intestinal system [7,8,9]

The GLP-1R is expressed in many tissues, including pancreatic islets, the central nervous system, lung, kidney, heart, intestine, and also on immune cells ( When secreted by L cells, GLP-1 either functions in an endocrine manner, being released into the blood stream where it is rapidly inactivated by DPP-4 with a half-life of about 2 min, or exerts paracrine effects like stimulating neurons

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