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These preclinical insights have been validated in large-scale clinical trials.The FLOW trial (n = 3,533) showed that once-weekly subcutaneous administration of semaglutide (1.0 mg) significantly reduced the risk of a renal composite endpointincluding 50% decline in eGFR, renal failure, or cardiovascular deathby 24% in patients with T2DM and chronic kidney disease (CKD) (HR = 0.76, 95% CI: 0.660.88

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Nevertheless, any significant or persistent hair loss warrants medical evaluation to exclude other contributing factors

Nonetheless, patients and practitioners should treat it with the same respect as any adjunct therapy: monitor its effects, watch for rare side effects, and ensure it complements the overall treatment plan

funding acquisition, R.H

[DOI] [PubMed] [Google Scholar] 222.European Medicines Agency
