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Metabolic reprogramming in liver fibrosis

This decision has angered many compounders who are using semaglutide to make weight-loss drugs

Int J Mol Sci 2020

However, as only male rats were tested in the aforementioned study, and since PPG neuron activation was recently shown to have divergent effects on food-motivated behavior and palatable food intake in male vs female rats (51), it is also likely that this PPG neuron accommodation disinhibits female behavior more, contributing to the higher prevalence of binge-like behavior in females, a speculation that needs to be tested

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The stakes are real: semaglutide and tirzepatide are peptide medications that degrade when exposed to heat, freezing, or prolonged light exposure