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One promising optimization strategy involves the use of mRNA-encapsulated LNPs, such as Cas9 mRNA, instead of Cas9 plasmid DNA

The primary metabolite, Des-lys1 pramlintide (2-37 pramlintide), is biologically active in vitro

Potential Role of Tirzepatide in the Treatment of MASH Although maintaining an adequate body weight, eating healthy, and exercising regularly is the best treatment for MAFLD, more research on tirzepatide has shown it to be an effective treatment for MASH patients [43]

Acknowledgements This research is supported by Agency for Science, Technology and Research (A*STAR), Singapore under its Industry Alignment Pre-Positioning Fund (Grant No
