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While semaglutide alone rarely causes hypoglycemia, an overdose can push blood sugar dangerously low, especially if combined with other diabetes medications

This heightened sensitivity reflects the combined effect of delayed gastric emptying, reduced stomach capacity, and the appetite-suppressing effects of the medication itself

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The authors reported statistically significant mean reductions in HbA1c and greater mean reductions in body weight in the retatrutide groups relative to both placebo and active control

The concerns that arose in the meta-analysis caused a desire to study this topic deeper, she says, adding that the Food and Drug Administration (FDA) is currently investigating several safety concerns with semaglutide and has added blood clots to the investigation
