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Dies sollte bei der Behandlung von Patienten mit eingeschrnkter Nierenfunktion bercksichtigt werden, da belkeit, Erbrechen und Durchfall zu Dehydrierung fhren knnen, die eine Verschlechterung der Nierenfunktion verursachen kann

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Pancreatic beta-cell mass in European subjects with type 2 diabetes

Methods We combined data from several Swedish Registers and identified patients with incident type 2 diabetes being treated with GLP-1 RAs between 2006 and 2015, and matched them to diabetic patients who did not use GLP-1 RAs as the comparisons

First-generation short-acting agents (exenatide and lixisenatide), with twice-daily or once-daily administration provided proofs of concept for incretin-based therapy but required frequent injections and offered modest efficacy

Although these agents produce substantial and sustained weight reduction, emerging clinical observations suggest that chronic therapy may be accompanied by changes in lean mass trajectory, reduced protein intake, and micronutrient insufficiency