first large study of glp 1 receptor agonists during pregnancy Should GLP-1 be continued into early pregnancy? ➡️ Swipe to read the key takeaways from a recent target trial emulation on first-trimester GLP-1 receptor agonist use and Maternal cardiometabolic health and the
Description
Two-hour postprandial glucose decreased by 61.3 mg/dL using the combination drug versus 10.8 mg/dL with placebo

Safety is a critical factor to consider when evaluating long-term cardiometabolic therapies

The following variables were included in a logistic regression model used to estimate propensity scores (PS): age, gender, pre-existing cardiovascular disease (coronary heart disease, stroke, transient ischemic attack, acute myocardial infarction, peripheral vascular disease) and heart failure

Furthermore, limited data exist regarding long-term weight maintenance, treatment discontinuation, and weight regain following cessation of therapy

Between 10 percent and a quarter experienced vomiting, depending on the dose

POMC, Pro-opiomelanocortin
