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Targeted ablation of glucosedependent insulinotropic polypeptideproducing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet

10.1016/j.mce.2013.11.010 [DOI] [PubMed] [Google Scholar] Salinas, C

There were no significant difference in the expression of SESN2, LC3II and p62 among siSESN2, siSESN2 + PA and siSESN2 + PA + liraglutide groups

Declaration of competing interest The authors have no conflicts of interest

Oxidative RNA damage can impair protein translation, and damaged RNA can degrade prematurely, further impairs the synthesis of essential proteins ( Regarding mitochondrial dysfunction involved in AD pathophysiology, it includes disturbances in oxidative phosphorylation (OXPHOS), and impaired energy metabolism as well as excess generation of ROS, altered mitochondrial biogenesis, transport and dynamics ( Autophagy Autophagy is an important pathway in removing abnormal protein aggregates in cells and plays an essential role in protein homeostasis ( Diagnostics and treatments of AD Due to severe cognitive impairment in patients with advanced AD, the cost of treatment and care seriously affects economic development (78)

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