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These are often mild and temporary
However, Januvia requires dose adjustment in patients with renal impairment specifically, a reduction to 50 mg for eGFR 3044 and 25 mg for eGFR below 30
Or turning your phone off an hour or two before bedtime instead of staying up scrolling
Most compounding pharmacies default to this because it balances ease of measurement with reasonable injection volumes across the dose escalation range

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That's the sweet spot for muscle preservation
