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Phase 2 trials have also highlighted other possible side effects, like injection site reactions

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by alzheimers disease- associated abeta oligomers

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Differences between groups were compared via two-tailed unpaired t tests for two groups, one-way analysis of variance (ANOVA) followed by Dunnetts multiple comparison test for multiple groups, or two-way repeated-measures ANOVA followed by the Bonferroni multiple comparison test for multiple groups and time courses