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Molecular basis for hormone recognition and activation of corticotropin-releasing factor receptors

Ferreira JP, Fitchett D, Ofstad AP, Kraus BJ, Wanner C, Zwiener I, et al

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We have established a high-throughput means with which to assess GPCR agonist or antagonist action using a clonal HEK293-H188-C24 cell line, or adenovirus that allow viral transduction of HEK293 cells with H188

A robust sandwich covariance matrix estimator was used in the Cox model analyses to account for the re-use of stable use sets of insulin in the matching for GLP-1RA users (Additional file 1: Fig

However, they do not contain actual GLP-1 or its direct synthetic counterparts, which are the basis of prescription GLP-1 receptor agonist medications