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Understanding this dual role has important therapeutic implications, as G protein-biased GLP-1 receptor agonists with reduced -arrestin recruitment show enhanced anti-hyperglycemic efficacy through avoidance of receptor desensitization, while the requirement for -arrestin-2 in ERK/CREB activation at therapeutic concentrations explains why complete elimination of -arrestin-2 recruitment may not be optimal for all applications

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1 Nonmotor symptoms are a separate category of symptoms that patients with PD may experience that do not affect movement but are still negatively impactful

Alcohol also adds empty calories and can affect blood sugar regulation