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It mimics the action of GLP-1, a hormone produced in the intestines that stimulates insulin secretion and suppresses glucagon release

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Functional imaging studies show that GLP-1R agonists blunt neural responses to reward cues in the ventral tegmental area and nucleus accumbens, and retrospective and early prospective data link their use to reduced intake of alcohol and nicotine

It can not only influence the fasting blood glucose of patients but also decrease the postprandial blood glucose of patients and have an impact on the glycosylated hemoglobin (HbA1c) of patients (68)

Anti-Apoptotic and Anti-Oxidative Effects The drugs activate anti-apoptotic proteins and block pro-apoptotic pathways to protect cardiomyocytes against ischemia and oxidative stress [30]

The company is exploring higher-dose formulations and has signalled plans to investigate the full weight-loss potential of the combination in further studies