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[DOI] [PMC free article] [PubMed] [Google Scholar] 35.Coskun T., Urva S., Roell W.C., Qu H., Loghin C., Moyers J.S., OFarrell L.S., Briere D.A., Sloop K.W., Thomas M.K., et al
Results Development of the secreted Exe4 peptide-coding gene To develop a one-shot in vivo genome editing-based therapy for DIO and pre-diabetes, we targeted the liver due to its large size and ease of transduction, anticipating effective therapeutic peptide/protein production and secretion following successful genome editing (Fig

JACC Basic Transl Sci 5:63244

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Worthington E