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Stefan Macher: declares no conflict of interest relevant to this study

BrightFocus Foundation Additional Phase 2/3 programs: Parallel GLP-1 and dual-agonist studies (e.g., tirzepatide) are exploring cognition, imaging, and fluid biomarkers

In addition, the very concept of synthetic peptides opens up many unknown possibilities for tirzepatide

Overall, these results demonstrate that GLP-1 RAs may exert their therapeutic effects through multiple mechanisms in MASH treatment

For persistent symptoms, intra-articular corticosteroid injections or duloxetine may be appropriate adjunctive therapies

I feel so much better already