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Milton Packer, the study found that tirzepatide reduced the combined risk of cardiovascular death or worsening heart failure by 38% (HR 0.62) over a median of 104 weeks

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Patients were also excluded if they met the ASA physical status classification of ASA 4 (patients with severe systemic disease threatening life) or ASA 5 (patients who were not expected to survive without surgery) (11)

Kim, Fiscal impact of expanded Medicare coverage for GLP-1 receptor agonists to treat obesity in JAMA Health Forum (2025
