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It can avoid adverse reactions and potential risk of pancreatic gland degeneration caused by direct insulin treatment (2)

Patients using Contrave lost an average of 5% to 10% of their body weight over a year

Systemic insulin resistance and consequent dysregulation in homeostatic glycaemic status are the key mediators of the chronic complications associated with uncontrolled T2DM and metabolic syndrome, both in the form of microvascular disease (retinopathy, neuropathy, nephropathy) and macrovascular complications (stroke and coronary artery disease) [206,207]

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109 A number of pharmacological agents can be used, although high-quality evidence to support these therapies is currently lacking

Some patients may experience headache or fatigue , particularly in the early stages of treatment