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S., Urban, B

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This prior exposure may slightly blunt the initial appetite-suppressing effects of retatrutide GLP-1 component, though the additional GIP and glucagon pathways will still be novel

Given this background and the fact that the apparent potency of ALT-801 for the GLP-1R is comparable to that of semaglutide (EC 50 of 39 pM and 15 pM, respectively 20 ) it is reasonable to conclude that GCGR activation is responsible for the improved activity of ALT-801 over semaglutide in this NASH model

1 Semaglutides are not a magic bullet

Two of the most essential hormones the human gut secretes are GLP-1 and GIP (Gastric Inhibitory Polypeptide)