glp 1 and gip receptor agonist Mechanisms of action therapeutic applications of GLP-1 and dual GIP/GLP-1 agonists Mechanisms of action and therapeutic

By summarizing the results of t...

Although these mechanisms have been exploited to facilitate weight loss, these medications have also been indicated for patients with cardiovascular or renal diseases, all of which have caused a recent drastic rise in prescribing GLP-1 RAs

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The responsible message: Substantial weight loss usually includes some loss of lean tissue

Methods This is a cohort study combining several population-wide databases and covering a Spanish population of five million inhabitants, including all adults with obesity who initiated treatment with either GLP-1RA or SGLT-2i for type 2 diabetes from 2015 to 2021

This Comment highlights emerging evidence and advocates for clinical strategies that prioritize muscle preservation to ensure the long-term success and safety of pharmacological weight management.