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The GWAS was performed including covariates as described in equation 1 above, with the addition of five genetic principal components to account for fine-scale genetic ancestry, and indicator variables to account for variation in the genotyping platform

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Berberine functions through a different pathway

half of the participants treated with semaglutide (50.5%) had a weight reduction of 15% compared with 4.9% assigned to placebo 20

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