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Prescribing clinician specialty Among patients with available prescribing data (65.2% of the total population), most oral semaglutide prescriptions were written by general practice providers (92.8%)

Mol Metab 7: 90101, 2018

JWU-A021 avoids such non-specificity since it is not an electrophile and most likely acts independently of covalent TRPA1 channel modification

Side effect comparison All three compounds share a similar gastrointestinal side effect profile, which is expected given that all three activate the GLP-1 receptor

For example, GLP-1 agonists have been shown to increase beneficial bacteria such as Bacteroides, Lactobacillus, and Bifidobacterium, while reducing inflammatory species with Enterobacteriaceae

Interestingly, appetite-related sensations were mostly similar to placebo and liraglutide when assessed postprandially after a lunch buffet