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In the SURPASS-2 trial, patients with obesity and T2D who received tirzeapatide (5 mg weekly) achieved greater HbA1c and body weight reductions than those receiving semaglutide (1 mg weekly) during the 40 week study (64) despite comparable putative GLP-1R occupancy at these doses (65)

Less iron in your blood limits the amount of oxygen that your blood can carry around your body

Oral delivery of semaglutide and tirzepatide using milk-derived small extracellular vesicles