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Animal studies provide valuable information, but this often means more research is required before it applies to humans

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Hsd11b1 and Hsd11b2 cooperatively regulate intracellular glucocorticoid activity: Hsd11b1 catalyzes the activation of inactive cortisone to cortisol, whereas Hsd11b2 inactivates cortisol by converting it to cortisone

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Most patients return to their pre-treatment weight within approximately 18 months of stopping

Matthews DR, Paldnius PM, Proot P, Chiang Y, Stumvoll M, Del Prato S, VERIFY study group
