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In contrast, all three targetsGLP-1R, GIPR, and GCGRcontributed favorably to correcting dyslipidemia, evidenced by their effects on raising HDL-C and lowering triglycerides, suggesting a shared mechanism for improving systemic lipid metabolism

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Drug Design, Development and Therapy, 16, 4449-4461

All of the compounds were prepared as solutions in isotonic saline and dosed as s.c

Interestingly, the previously observed positive contrast effect was spared in S2, with a weaker residual effect specifically on the consumption of the more palatable pellet type