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Following commencement, patients should be monitored for hyperkalaemia (Box 3)

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Mawardi HH et al

Semaglutide's seven-day half-life means drug levels drop significantly after one week, reducing appetite suppression and potentially causing side effects when you resume dosing

In the HARMONY study (n = 9463 patients with established coronary heart disease, cerebrovascular disease, or peripheral vascular disease), albiglutide, despite lowering MACE, had no effect on the risk of fatal or nonfatal stroke in the subgroup analysis during a follow-up of 1.6 years [18]

But a list price of around $1,000 per month or more means the treatments are out of reach for many patients