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This biphasic release pattern has been thought to reflect activation of separate populations of Lcells as nutrients progress through the gastrointestinal tract

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Most cases of constipation are mild to moderate and tend to improve as the body adjusts to the medication, typically within the first few weeks to months of treatment

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[DOI] [PMC free article] [PubMed] [Google Scholar] 119.Kobori T., Onishi Y., Yoshida Y., Tahara T., Kikuchi T., Kubota T., Iwamoto M., Sawada T., Kobayashi R., Fujiwara H., et al