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Because the half-life is about 5 days and you dose weekly, blood levels rise for the first 4 weeks before stabilizing
Most researchers report reduced hunger within the first 3-5 days
Mazdutide needs longer-term data at higher doses to demonstrate comparable sustainability
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doi: 10.1016/S2213-8587(24)00157-8 3 OngKLStaffordLKMcLaughlinSABoykoEJVollsetSESmithAEet al
Some users also find that elevating the head of their bed slightly helps prevent nighttime reflux regardless of injection timing
