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Samsonov et al

Gallbladder Issues : There is evidence that semaglutide may increase the risk of gallstones or inflammation of the gallbladder (cholecystitis)

To meet metabolic goals and support digestive health, managing issues tied to constant hunger cues while eating a balanced diet is key

Long-term use of progestogens can also cause abnormal bleeding due to atrophy of the endometrium

Ongoing monitoring: Expect periodic A1C testing, immediate reporting of dose changes/side effects and re-grounding after each dose adjustment as required

These disorders can be associated with insulin resistance, hyperglycemia-induced damage, oxidative stress, astrocyte abnormalities, and mitochondrial dysfunction, resulting in insufficient energy supply, altered synaptic plasticity, death of neuronal cells, as well as functional and structural damage to reward networks