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Staying at the starting dose for six or even eight weeks is reasonable if side effects are significant

Skin bacteria transferred from fingers to the stopper can contaminate the vial over time, and contamination shortens usable life dramatically

Another critical consideration is affordability

Ryan DH, Yockey SR

Evaluation Baseline data, including patient age, height, initial weight, body composition and body morphology, as well as glucose and lipid metabolism levels, such as fasting blood glucose, glycated haemoglobin, total cholesterol, triglycerides, low-density lipoprotein (LDL), high-density lipoprotein (HDL), insulin resistance index

As a GIP receptor agonist, tirzepatide enhances insulin secretion in a glucose-dependent manner, reduces glucagon secretion, and may improve insulin sensitivity