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Rapid weight loss from GLP-1 medications like semaglutide can increase gallstone formation risk
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Serious / Rare Side Effects Angioedema rare but life-threatening (less common than ACE inhibitors) Acute kidney injury especially in patients with bilateral renal artery stenosis Hyperkalemia requires monitoring 5

ClinicalTrials.gov identifiers NCT01572753, NCT01619345, NCT02014259, NCT02016911, NCT02249871, NCT02172313, NCT02877355.