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Discontinuation rate: Only 1-2% stop during this period Psychological state: Highly motivated, visible results drive continued adherence Key achievement: Halfway to goal with strong momentum Weeks 25-36: The Steady State Phase (12mg Maintenance) Starting Weight Week 25: ~182 pounds | Expected Weight Week 36: 174-178 pounds | Net Loss This Period: 4-8 pounds | Total Loss: 42-46 pounds Whats Happening Physiologically Metabolic adaptation intensifies

In Canada, the prevalence of obesity increased three-fold over the last three decades and now affects one in four adults, according to Obesity Canada

Nevertheless, some beneficial effects of GLP-1RAs on albuminuria and reducing the progressive loss of kidney function have been demonstrated in LEADER, SUSTAIN 6, and REWIND (5, 6, 9, 19) and a GLP-1RA with proven CVD benefit is recommended in patients with CKD if SGLT2is are not tolerated or are contraindicated, or if eGFR is less than adequate (18)

For many individuals, Isotretinoin results in long-term remission of acne, with permanent improvement in skin condition