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GLP-1Rs are highly expressed in the frontal cortex, hypothalamus, thalamus, hippocampus, cerebellum, and substantia nigra pars compacta (SNpc) [9, 41]

Patients should be on the lookout for sudden warmth, sweating, and redness, particularly in the upper body

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GLP-1 agonist and weight

They showed that semaglutide enhanced histological parameters of fibrosis and inflammation while decreasing hepatic expression of genes associated with fibrotic and inflammatory cascade: through proteomic profiling of serum from MASH patients treated with semaglutide, they detected 72 proteins linked to disease resolution and validated these findings in preclinical mouse models and an independent patient cohort [28]