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At low doses, GLP-1 agonists have been observed to reduce alcohol cravings, lower the frequency and volume of drinking and in some individuals produce a natural disinterest in alcohol altogether

41.5% had a history of MI or stroke

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As presented at the American Diabetes Association Meeting: this randomized phase 2b trial in 230 adults with overweight or obesity shows that aleniglipron, an oral small-molecule GLP1-RA, led to up to 11.3% body-weight loss compared with placebo after 36 weeks of treatment.