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Yerba mate may contribute to a small caloric deficit through increased expenditure, but it cannot replace the sustained appetite reduction and metabolic changes produced by GLP-1 receptor agonism

Similarly, the substudy of the obesity phase 2 trial showed clear promise for retatrutide in the treatment of MASLD [47], and through its GCG receptor agonism, retatrutide may offer benefits beyond WL, through weight-independent metabolic effects at the liver [40]

These changes can shift the makeup of the microbiome

Change in overweight from childhood to early adulthood and risk of type 2 diabetes

Glucagon-like peptide-1 receptor (GLP-1R) belongs to the B family of G protein-coupled receptors (GPCRs)

In Brazil, for example, the GLP-1 market could more than quadruple, with generic competition potentially reducing prices by up to 70%