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Intense, unrelenting pain that is not relieved by rest or usual pain management strategies could indicate a more serious condition, such as a spinal fracture, infection, or tumor

Janumet XR is contraindicated in severe renal impairment, including an estimated glomerular filtration rate below 30 mL/min/1.73 m2
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doi: 10.1038/npp.2015.220

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The vials were centrifuged at 2000 g for 5 min at room temperature, and 1.5 mL of supernatant was collected
