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Additionally, GIPR antagonists also exhibit improvement of metabolism on obese mice57 and GIPR agonists or antagonists both show therapeutical effects in combination with GLP-1R agonists.58 A GLP-1R agonist/GIPR antibody (antagonist) fused protein was reported promoting body weight loss.59 Nevertheless, whether a GLP-1R agonist/GIPR antagonist can improve T2DM needs more evidences

McGee, Its not the right approach for everyone, but it can be a valuable option to discuss with a healthcare provider as part of a broader, individualized plan." In clinical practice, Ive seen GIP/GLP-1-based medications be a helpful option for some patients with PCOS, particularly when insulin resistance and weight management are part of the picture

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Select lower-sodium, nitrate-free versions to reduce salt retention while keeping hunger controlled