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Flexible Titration Baseline: Specially designed to allow a seamless transition from the initial 0.25mg activation dose (weeks 14) straight up to the 0.5mg optimization dose (weeks 5+) using the same stable platform

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Method We systematically searched PubMed and Embase from inception to 1 May 2025 for cohort studies comparing the effect of combination therapy with SGLT2 inhibitor or GLP-1 RA monotherapy on (cardiovascular) mortality and cardiovascular or kidney endpoints in individuals with type 2 diabetes